Bridging fundamental and clinical science using biobanked samples Translational science refers to research performed in a lab, or fundamental research, which is then applied to patients in a clinical setting. It is unquestionably important to moving forward in the fight against cancer. This type of research requires collaborations [...]

Testing the effectiveness of panobinostat in diffuse large B-cell lymphoma In cells, DNA is wrapped around organizing proteins called histones. Different enzymes interact with the histones to make DNA more or less available to the cell. The histone modifying enzymes are known to be mutated in many diffuse [...]

Predicting patient responsiveness to PARP inhibitors Patients suffering from ovarian cancer, whose cancers are known to have mutated BRCA genes, can be treated with drugs known as PARP inhibitors. Unfortunately, not every patient responds to this treatment. RRCancer Researchers Drs. A-M Mes-Masson, D. Provencher, and P. Tonin compared [...]

Immunotherapy targets in ovarian cancer CD73 is an enzyme found on cell surfaces that can dampen the immune system responses. Already known to be involved in tumour progression and metastasis, a collaboration of RRCancer researchers (including the team of Dr. J. Stagg and 3 other network members) found [...]